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November 1, 1993Acta Physiologica Scandinavica

Alteration of cardiac energy state during development of hypertension in rats of the Lyon strain: a 31 P‐NMR study on the isolated rat heart

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Population

Perfused hearts from Lyon strains of hypertensive, normotensive and hypotensive rats at the ages of 12 and…

Comparison

Increasing cardiac workload by varying… vs Normotensive and hypotensive rats, and…

Design

Preclinical

Authors

SLS. LortetCentre National de la Recherche ScientifiqueMHManfred HeckmannUniversity of WürzburgJAJ. AussedatCentre National de la Recherche Scientifique

Discussion

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Implication

Should not alter clinical hypertension management; leaves open whether early metabolic adaptation translates to human disease.

Structured PICO

P
Population
Perfused hearts from Lyon strains of hypertensive (LH), normotensive (LN) and hypotensive (LL) rats at the ages of 12 and 21 weeks
I
Intervention
Increasing cardiac workload by varying extracellular calcium concentration in the perfusion fluid
C
Comparator
Normotensive (LN) and hypotensive (LL) rats, and comparison between 12-week and 21-week old rats
O
Outcome
Cardiac energy state (concentrations of ATP, phosphocreatine [PCr], inorganic phosphate [Pi], and intracellular pH) measured by 31P-NMR spectroscopysurrogate

During the development of hypertension in rats, cardiac oxidative metabolism is maximally activated early on as an adaptive response, which later transitions to a compensatory stage.

Cite This Study

Lortet et al. (1993) studied this question.

synapsesocial.com/papers/6a714cc535aa2c282ce29babhttps://doi.org/10.1111/j.1748-1716.1993.tb09626.x

Topics

Hypertension management
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Also Consider

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  1. 1The economy of isometric force development, myosin isoenzyme pattern and myofibrillar ATPase activity in normal and hypothyroid rat myocardium.1985 · 209 citations
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  3. 3Contraction and recovery of living muscles studied by 31p nuclear magnetic resonance1977 · 295 citations
  4. 4Pharmacology of Cardiac and Vascular Remodeling1995 · 34 citations
  5. 5Left ventricular failure induced by long-term hypertension in rats.1990 · 118 citations