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September 23, 2009European Journal of Surgical OncologyOpen Access

Anastomotic leakage after colon cancer surgery: A predictor of significant morbidity and hospital mortality, and diminished tumour-free survival

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Why the study?

Does anastomotic leakage after colon cancer surgery affect perioperative morbidity, hospital mortality, and long-term tumour-free survival?

Population

28,271 patients who underwent resection of colon cancer

Comparison

Anastomotic leakage following resection of colon… vs No anastomotic leakage

Design

Cohort

Follow-up

5 years

Authors

RKRainer KubeMedical College of WisconsinPMPaweł MroczkowskiUniversity Hospitals of the Ruhr-University of BochumDGD. GranowskiKlinik und Poliklinik für Kinder- und Jugendmedizin

Discussion

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Member takes

Overview

AL after colon cancer resection identifies high-risk patients; leaves open whether prevention improves survival.

Structured PICO

Does anastomotic leakage after colon cancer surgery affect perioperative morbidity, hospital mortality, and long-term tumour-free survival?

P
Population
28,271 patients who underwent resection of colon cancer (844 with anastomotic leakage, 27,427 without anastomotic leakage)
I
Intervention
Anastomotic leakage (AL) following resection of colon cancer
C
Comparator
No anastomotic leakage
O
Outcome
Hospital mortality, AL-associated post-operative morbidity, and long-term oncological result (five-year survival and tumour-free survival)hard clinical

Anastomotic leakage after colon cancer resection is associated with significantly higher hospital mortality and poorer long-term oncological outcomes.

Cite This Study

Kube et al. (2009) studied this question.

synapsesocial.com/papers/6a714dca75498292b70ac926https://doi.org/10.1016/j.ejso.2009.08.011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anastomotic Leakage Is Predictive of Diminished Survival After Potentially Curative Resection for Colorectal Cancer2004 · 462 citations
  2. 2Prognosis After Anastomotic Leakage in Colorectal Surgery2005 · 471 citations
  3. 3Anastomotic Leakage after Colorectal Cancer Surgery: A Risk Factor for Recurrence and Poor Prognosis1993 · 113 citations
  4. 4Risk Factors and Oncologic Impact of Anastomotic Leakage after Rectal Cancer Surgery2008 · 279 citations
  5. 5The management and outcome of anastomotic leaks in colorectal surgery2007 · 171 citations