October 27, 2006AJP Heart and Circulatory Physiology

H2O2 activates redox- and 4-aminopyridine-sensitive Kv channels in coronary vascular smooth muscle

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Population

Coronary artery smooth muscle cells

Comparison

Hydrogen peroxide (H2O2) at 1 and 10 mM vs Baseline/control conditions and various channel…

Design

Preclinical

Authors

PRPaul A. RogersOchsner Medical Center WCWilliam M. ChilianHeart Failure & Transplant IBIan N. BratzNortheast Ohio Medical University

Discussion

Member takes

Implication

Animal data support redox-sensitive KV channels in coronary vessels; leaves open human translation and therapeutic relevance.

Structured PICO

Population

Coronary artery smooth muscle cells

Intervention

Hydrogen peroxide (H2O2) at 1 and 10 mM

Comparator

Baseline/control conditions and various channel inhibitors (Dithiothreitol, N-ethylmaleimide, tetraethylammonium, iberiotoxin, 4-aminopyridine)

Outcome

K+ current amplitude and voltage of half-activation and inactivationsurrogate

H2O2 increases the activity of 4-AP-sensitive KV channels, supporting the concept that these channels are redox-sensitive and contribute to H2O2-induced coronary vasodilation.

Cite This Study

Rogers et al. (2006) studied this question.

synapsesocial.com/papers/6a71504435aa2c282ce29eb4 https://doi.org/10.1152/ajpheart.00696.2006

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H2O2 activates redox- and 4-aminopyridine-sensitive Kv channels in coronary vascular smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

H2O2 activates redox- and 4-aminopyridine-sensitive Kv channels in coronary vascular smooth muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider