Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 12, 2022Avicenna Journal of Medical BiochemistryOpen Access

Resistance training significantly increased PI3K expression (P=0.028), AKT1 expression (P=0.032), and weight ratios of left ventricular to heart, heart to body, and left ventricular to body (all P=0.001) compared to control diabetic rats.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

The impact of resistance exercise on cardiac tissue PI3K and AKT1 expression and physiological cardiac hypertrophy in type 2 diabetes remained to be determined.

Does a 6-week resistance exercise program improve PI3K/AKT1 gene expression and physiological cardiac hypertrophy in type 2 diabetic rats?

Population

21 male Wistar rats (220±20 g) with diet-induced obesity

Comparison

Exercise diabetes vs control T2D vs non-diabetes

Design

Randomized preclinical animal study

Follow-up

6 weeks

Authors

MDMohammad DastyarMEMojtaba EizadiMRMania Roozbayani

Discussion

Loading...

Member takes

Overview

Hypothesis-generating in T2D rat models; leaves open translation to human cardiac hypertrophy or exercise protocols.

Structured PICO

Does a 6-week resistance exercise program improve PI3K/AKT1 gene expression and physiological cardiac hypertrophy in type 2 diabetic rats?

P
Population
21 male Wistar rats (220±20 g) made obese with 6-week high-fat diet (HFD) and induced with type 2 diabetes via streptozotocin (25 mg/kg)
I
Intervention
6-week resistance exercise program, 5 sessions per week
C
Comparator
Control diabetic rats (no exercise) and non-diabetic rats
O
Outcome
Expression of PI3K and AKT1 in cardiac tissue, and weight ratio of left ventricular to heart, heart to body, and left ventricular to bodysurrogate

Resistance training induces physiological cardiac hypertrophy in diabetic rats, potentially mediated by the PI3K/AKT1 signaling pathway.

Cite This Study

Dastyar et al. (2022) studied this question.

synapsesocial.com/papers/6a715095e71d69abee092a24https://doi.org/10.34172/ajmb.2022.2321
View Full Paper
Ask AI
Bookmark
Share