Why the study?
Does dronedarone alter the pharmacokinetics and pharmacodynamics of metoprolol in healthy male subjects?
Does dronedarone alter the pharmacokinetics and pharmacodynamics of metoprolol in healthy male subjects?
Dronedarone increases the bioavailability of metoprolol in CYP2D6 extensive metabolizers and induces a modest, dose-dependent negative inotropic effect.
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Coadministration warrants caution for metoprolol overexposure in CYP2D6 extensive metabolizers; confirms genotype-specific pharmacokinetic interaction.
Damy et al. (2004) studied this question.
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