Why the study?
Does co-administration of amiodarone increase the serum concentration/dose ratio of metoprolol in patients with cardiac arrhythmia?
Population
120 inpatients with cardiac arrhythmias
Comparison
Co-administration of metoprolol and amiodarone vs Metoprolol alone
Design
Cohort
Authors
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May warrant metoprolol monitoring with amiodarone co-use; leaves open whether interaction requires routine dose adjustment in arrhythmia patients.
Does co-administration of amiodarone increase the serum concentration/dose ratio of metoprolol in patients with cardiac arrhythmia?
Co-administration of amiodarone significantly increases the serum concentration/dose ratio of metoprolol, likely via CYP2D6 inhibition by desethylamiodarone, necessitating careful monitoring.
Fukumoto et al. (2006) studied this question.
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