Why the study?
In diabetic cardiomyopathy, LV diastolic dysfunction is an early sign of cardiac involvement, and the authors aimed to explore LV diastolic function using ECG-gated 18F-FDG PET imaging beyond assessing cardiac glucose utilization in a diabetic rat model.
Does ECG-gated 18F-FDG PET imaging detect early LV diastolic dysfunction in a rat model of diabetic cardiomyopathy?
Does ECG-gated 18F-FDG PET imaging detect early LV diastolic dysfunction in a rat model of diabetic cardiomyopathy?
ECG-gated 18F-FDG PET imaging can detect early LV diastolic dysfunction prior to systolic impairment in a diabetic rat model, suggesting potential for early HF detection in type 2 diabetes.
May inform preclinical imaging of early diastolic dysfunction in diabetes; leaves open human validation and clinical translation.
In diabetic cardiomyopathy, left ventricular (LV) diastolic dysfunction is one of the earliest signs of cardiac involvement prior to the definitive development of heart failure (HF). We aimed to explore the LV diastolic function using electrocardiography (ECG)-gated 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET) imaging beyond the assessment of cardiac glucose utilization in a diabetic rat model. ECG-gated 18 F-FDG PET imaging was performed in a rat model of type 2 diabetes (ZDF fa/fa) and ZL control rats at age of 13 weeks (n = 6, respectively). Under hyperinsulinemic-euglycemic clamp to enhance cardiac activity, 18 F-FDG was administered and subsequently, list-mode imaging using a dedicated small animal PET system with ECG signal recording was performed. List-mode data were sorted and reconstructed into tomographic images of 16 frames per cardiac cycle. Left ventricular functional parameters (systolic: LV ejection fraction (EF), heart rate (HR) vs. diastolic: peak filling rate (PFR)) were obtained using an automatic ventricular edge detection software. No significant difference in systolic function could be obtained (ZL controls vs. ZDF rats: LVEF, 62.5 ± 4.2 vs. 59.4 ± 4.5%; HR: 331 ± 35 vs. 309 ± 24 bpm; n.s., respectively). On the contrary, ECG-gated PET imaging showed a mild but significant decrease of PFR in the diabetic rats (ZL controls vs. ZDF rats: 12.1 ± 0.8 vs. 10.2 ± 1 Enddiastolic Volume/sec, P < 0.01). Investigating a diabetic rat model, ECG-gated 18 F-FDG PET imaging detected LV diastolic dysfunction while systolic function was still preserved. This might open avenues for an early detection of HF onset in high-risk type 2 diabetes before cardiac symptoms become apparent.
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Werner et al. (2018) studied this question.
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