August 3, 2012EJNMMI ResearchOpen Access

Left ventricular functional assessment in murine models of ischemic and dilated cardiomyopathy using 18 FFDG-PET: comparison with cardiac MRI and monitoring erythropoietin therapy

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Population

22 mice including murine models of ischemic cardiomyopathy, dilated cardiomyopathy, and healthy controls.

Comparison

ECG-gated [18F]FDG-PET imaging; and in a… vs 1.5 T cardiac MRI for imaging comparison; saline…

Design

Preclinical, Mice were randomised into groups (for the treatment sub-study).

Follow-up

4 weeks (for treatment sub-study)

Authors

SBStefan BrunnerHeart Failure / Cardiomyopathy ATAndrei TodicaGerman Society of Surgery GBGuido BöningLMU Klinikum

Discussion

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Implication

ECG-gated FDG-PET may enable serial LVEF monitoring in murine cardiomyopathy models; leaves open validation against MRI for treatment effects.

Structured PICO

Population

22 mice including murine models of ischemic cardiomyopathy (ICM, n=7 male C57BL/6 with LAD occlusion), dilated cardiomyopathy (DCM, n=11 SWR/J infected with CVB3), and healthy controls (n=4).

Intervention

ECG-gated [18F]FDG-PET imaging; and in a treatment sub-study, Erythropoietin (EPO) 2000 IU/kg subcutaneous injections thrice weekly for 2 weeks.

Comparator

1.5 T cardiac MRI for imaging comparison; saline subcutaneous injections for treatment sub-study.

Outcome

Left ventricular volumes (end-diastolic volume [EDV] and end-systolic volume [ESV]) and left ventricular ejection fraction (LVEF).surrogate

ECG-gated FDG-PET is a feasible tool for longitudinal monitoring of left ventricular function in murine models of cardiomyopathy, though it systematically overestimates LVEF compared to MRI.

Limitations

Use of clinical 1.5 T MRI instead of dedicated small animal MRI
Observer-dependent valve plane definition in semi-automated MRI analysis
Delayed examination time-point for ICM mice (4 weeks post-MI) leading to advanced dilation
High dose of EPO may have induced polycythaemia

Cite This Study

Brunner et al. (2012) studied this question.

synapsesocial.com/papers/6a83822f48656d5c51fae57e https://doi.org/10.1186/2191-219x-2-43

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Implication

ECG-gated FDG-PET may enable serial LVEF monitoring in murine cardiomyopathy models; leaves open validation against MRI for treatment effects.

Left ventricular functional assessment in murine models of ischemic and dilated cardiomyopathy using 18 FFDG-PET: comparison with cardiac MRI and monitoring erythropoietin therapy

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Left ventricular functional assessment in murine models of ischemic and dilated cardiomyopathy using 18 FFDG-PET: comparison with cardiac MRI and monitoring erythropoietin therapy

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider