Key result
PET imaging with 18F-FDG accurately quantified left ventricular volumes in mice, demonstrating excellent correlation with cardiac MRI for end-diastolic (r=0.97) and end-systolic (r=0.96) volumes.
Why the study?
Does PET imaging accurately quantify left ventricular volumes and ejection fraction in mice compared to MRI?
Population
33 mice
Comparison
PET imaging using 18F-FDG with a semiautomatic… vs 6.3-T cardiac MRI using an ECG-triggered and…
Design
Preclinical
Authors
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Supports combined molecular-functional imaging in mouse models; leaves open translation to clinical use.
Cross-Sectional (n=33)
Does PET imaging accurately quantify left ventricular volumes and ejection fraction in mice compared to MRI?
Effect estimate: Correlation 0.97 for EDV, 0.96 for ESV, 0.86 for EF
PET imaging provides accurate and efficient quantification of left ventricular volumes and ejection fraction in mice, comparable to MRI, allowing combined molecular and functional imaging in a single scan.
Stegger et al. (2008) conducted a cross-sectional in Left ventricular pathophysiology in mouse models (n=33). PET imaging with 18F-FDG vs. Cardiac MRI was evaluated on Left ventricular end-diastolic volume (EDV), end-systolic volume (ESV), and ejection fraction (EF) (Correlation 0.97 for EDV, 0.96 for ESV, 0.86 for EF). PET imaging with 18F-FDG accurately quantified left ventricular volumes in mice, demonstrating excellent correlation with cardiac MRI for end-diastolic (r=0.97) and end-systolic (r=0.96) volumes.
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