July 3, 2014Journal of Cardiovascular Medicine
Colchicine for the prevention of pericarditis
Why the study?
Does colchicine prevent pericarditis in patients requiring primary or secondary prevention?
Structured PICO
Does colchicine prevent pericarditis in patients requiring primary or secondary prevention?
P
Population
1275 patients from 7 controlled clinical trials (5 double-blind RCTs, 2 open-label RCTs) focused on pharmacologic primary or secondary prevention of pericarditis.
I
Intervention
Colchicine
C
Comparator
Placebo
O
Outcome
Risk of pericarditis during follow-uphard clinical
Colchicine significantly reduces the risk of pericarditis for both primary and secondary prevention without a significant increase in adverse events or drug withdrawals.
Authors
Discussion
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Implication
Supports colchicine for pericarditis prevention; confirms benefit across primary and secondary settings.
Cite This Study
Imazio et al. (2014) studied this question.