Colchicine for Recurrent Pericarditis (CORP)
Why the study?
Does colchicine reduce the recurrence rate at 18 months in patients with a first recurrence of pericarditis?
Population
n=120 patients with a first recurrence of pericarditis, treated at 4 general hospitals in urban areas of…
Comparison
Colchicine, 1.0 to 2.0 mg on the first day… vs Placebo added to conventional treatment.
Design
RCT, Randomized, Double-blind, placebo-controlled
Follow-up
18 months
Authors
Discussion
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Implication
Supports adding colchicine to standard therapy for first recurrent pericarditis; confirms sustained efficacy through 18 months in this RCT.
Structured PICO
Does colchicine reduce the recurrence rate at 18 months in patients with a first recurrence of pericarditis?
P
Population
n=120 patients with a first recurrence of pericarditis, treated at 4 general hospitals in urban areas of Italy. Excluded: multiple recurrences and neoplastic or bacterial causes.
I
Intervention
Colchicine, 1.0 to 2.0 mg on the first day followed by a maintenance dose of 0.5 to 1.0 mg/d, for 6 months, added to conventional treatment.
C
Comparator
Placebo added to conventional treatment.
O
Outcome
Recurrence rate at 18 months.
Colchicine significantly reduces the recurrence rate of pericarditis when added to conventional treatment in patients with a first recurrence.
Limitations
- Multiple recurrences were excluded
- Neoplastic or bacterial causes were excluded
Cite This Study
Imazio et al. (2011) studied this question.