Why the study?
Does a 6-week interval between INR determinations compared to a 4-week interval increase the biologic risk of over- or underanticoagulation in patients with stable oral anticoagulation and a prosthetic mechanical heart valve?
Population
124 patients receiving stable oral anticoagulation treatment with a prosthetic mechanical heart valve for…
Comparison
Maximum interval between INR determinations of 6… vs Maximum interval between INR determinations of 4…
Design
RCT, randomized
Follow-up
2 years
Authors
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6-week INR monitoring does not increase out-of-range values in stable mechanical valve patients; supports extending intervals in selected cases.
Does a 6-week interval between INR determinations compared to a 4-week interval increase the biologic risk of over- or underanticoagulation in patients with stable oral anticoagulation and a prosthetic mechanical heart valve?
A 6-week interval for INR monitoring in stable patients with prosthetic heart valves does not increase the risk of out-of-range INR values compared to a standard 4-week interval.
Pengo et al. (2003) studied this question.
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