Why the study?
Does stable INR control reduce the occurrences of thromboembolism, bleeding, and death in patients on chronic warfarin therapy?
Population
6,073 patients on chronic warfarin therapy (2,504 stable and 3,569 comparator patients)
Comparison
Stable INR control vs Unstable INR control
Design
Cohort
Authors
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Stable INR control was associated with fewer events; leaves open whether extended monitoring intervals are safe in selected patients.
Does stable INR control reduce the occurrences of thromboembolism, bleeding, and death in patients on chronic warfarin therapy?
Patients with highly stable INR control on warfarin have lower rates of bleeding and thromboembolism, suggesting they may be safely monitored with intervals longer than the traditional 4 weeks.
Witt et al. (2009) studied this question.
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