Why the study?
Does recombinant factor VIIa normalize INR and prothrombin time in healthy volunteers receiving acenocoumarol?
Population
28 healthy volunteers receiving acenocoumarol to an International Normalized Ratio (INR) > 2.0
Design
Other
Follow-up
24 hours
Authors
Loading...
Supports low-dose rFVIIa for short-term VKA reversal; confirms dose-dependent INR normalization without systemic activation in RCT.
Does recombinant factor VIIa normalize INR and prothrombin time in healthy volunteers receiving acenocoumarol?
Recombinant factor VIIa effectively normalizes INR and prothrombin time in healthy volunteers treated with acenocoumarol without inducing systemic coagulation.
Erhardtsen et al. (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: