Key result
rFVIIa immediately restores hemostasis and normalizes INR in a patient with a warfarin-induced nosebleed.
Why the study?
Does recombinant activated factor VII improve haemostasis and normalize INR in patients with warfarin-induced bleeding?
Case Report (n=1)
Open-label
Yes
Does recombinant activated factor VII improve haemostasis and normalize INR in patients with warfarin-induced bleeding?
Recombinant activated factor VII may provide an immediate haemostatic effect and rapid INR normalization in patients with severe bleeding induced by vitamin K antagonists.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for rFVIIa in warfarin epistaxis; prospective trials needed before clinical adoption.
Haemorrhages represent a major complication of treatment with vitamin K antagonists. In cases of severe bleeding, a prompt effect on the increased International Normalized Ratio value is vital to achieve haemostasis. As conventional treatment, that is plasma or plasma-derived concentrates, carries the risk of blood-borne virus transmission, new treatments are needed. An open, multicentre pilot trial is currently under way to determine the effect of recombinant activated factor VII (rFVIIa; NovoSeven) administered to patients experiencing a bleeding episode after receiving vitamin K antagonists. When rFVIIa was given to a patient with a warfarin-induced nosebleed, it had an immediate haemostatic effect and the International Normalized Ratio value virtually normalized.
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Berntorp et al. (2000) conducted a case report in Bleeding episode after receiving vitamin K antagonists (n=1). Recombinant activated factor VII (rFVIIa; NovoSeven) was evaluated on Haemostatic effect and International Normalized Ratio (INR) normalization. Recombinant activated factor VII (NovoSeven) had an immediate haemostatic effect and virtually normalized the International Normalized Ratio in a patient with a warfarin-induced nosebleed.
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