Why the study?
How does blood fibrinolytic activity change after surgery in patients with and without malignant disease or deep vein thrombosis?
How does blood fibrinolytic activity change after surgery in patients with and without malignant disease or deep vein thrombosis?
Post-operative fibrinolytic shut-down is associated with malignant disease and deep vein thrombosis, driven by reduced activator release rather than a depleted store.
Answers are grounded in this paper and cite their sources.
Postoperative fibrinolytic shutdown may flag thrombosis risk in malignancy; leaves open whether targeting activator release alters outcomes.
The changes in blood fibrinolytic activity before and after operation have been investigated in 56 patients. The results have been analysed to assess the effect of the presence of malignant disease and the development of deep vein thombosis. The results show that patients with malignant disease and those with thrombosis have a fibrinolytic shut-down. This shut-down appears to be secondary to these two conditions and not the cause of the thrombosis. Patients without carcinoma and without thrombosis do not have a significant shut-down. The fibrinolytic shut-down results from a reduced release of activator from the peripheral store, not a reduction in the size of the store itself.
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Browse et al. (1977) studied this question.
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