Key result
Fibrinolytic activity of unaffected veins in patients with thrombosis and thrombophlebitis was significantly lower than in normal subjects, suggesting low activity predisposes to thrombosis.
Why the study?
Is fibrinolytic activity in the walls of veins lower in patients with thrombosis compared to healthy controls?
Population
77 individuals, comprising 58 patients with superficial thrombophlebitis and/or deep venous thrombosis of…
Comparison
Measurement of fibrinolytic activity in vein… vs Veins from healthy volunteers and patients…
Design
Case-control
Authors
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Reduced venous fibrinolytic activity was associated with thrombosis; hypothesis-generating and requires prospective validation before any clinical implications.
Case-Control (n=77)
Is fibrinolytic activity in the walls of veins lower in patients with thrombosis compared to healthy controls?
Patients with venous thrombosis have significantly lower fibrinolytic activity in their vein walls, suggesting this deficiency predisposes to thrombosis.
Pandolfi et al. (1969) conducted a case-control in Superficial thrombophlebitis and/or deep venous thrombosis (n=77). Superficial thrombophlebitis and/or deep venous thrombosis vs. Healthy volunteers and patients without thrombosis was evaluated on Fibrinolytic activity of biopsy specimens of veins. Fibrinolytic activity of unaffected veins in patients with thrombosis and thrombophlebitis was significantly lower than in normal subjects, suggesting low activity predisposes to thrombosis.
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