What is the clinical evidence from this study?

Study design: Systematic Review. Population: Venous thromboembolism. Intervention: Impaired fibrinolytic activity. Primary outcome: Venous thromboembolism.

What does this research mean for the field?

Impaired fibrinolytic activity lacks a proven association with symptomatic venous thrombosis, but is associated with an increased risk of postoperative thrombosis. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To critically evaluate the evidence supporting an association between impaired fibrinolytic activity and venous thromboembolism.

September 1, 1991Archives of Internal Medicine

A critical review of the evidence supporting a relationship between impaired fibrinolytic activity and venous thromboembolism

View Full Paper

Ask AI

Bookmark

Key result

Impaired fibrinolytic activity is linked to increased postoperative thrombosis risk but not symptomatic thrombosis.

Why the study?

Does impaired fibrinolytic activity increase the risk of venous thromboembolism?

Key Points

To critically evaluate the evidence supporting an association between impaired fibrinolytic activity and venous thromboembolism.
Conducted a comprehensive computer-assisted and manual literature search for articles evaluating fibrinolytic activity and venous thromboembolism.
Critically analyzed study designs, focusing specifically on diagnostic criteria for venous thromboembolism and the selection of control populations.
Published evidence fails to demonstrate a significant association between impaired fibrinolytic activity and increased risk of symptomatic venous thrombosis.
Impaired fibrinolytic activity measured either preoperatively or postoperatively associates with an increased risk of postoperative thrombosis.
Randomized clinical trials evaluating interventions to boost fibrinolytic activity produced inconsistent results, leaving the causality of the postoperative association unproven.

Study Design

Type

Systematic Review

Structured PICO

Does impaired fibrinolytic activity increase the risk of venous thromboembolism?

Population

Patients assessed for venous thromboembolism (symptomatic thrombosis or postoperative thrombosis)

Exposure

Impaired fibrinolytic activity (determined by global tests of fibrinolytic activity or specific tests for tissue plasminogen activator and plasminogen activator inhibitor)

Comparator

Normal fibrinolytic activity / control groups

Outcome

Venous thromboembolismhard clinical

This review found no proven association between impaired fibrinolytic activity and symptomatic venous thromboembolism, though an association exists for postoperative thrombosis.

Limitations

Whether the association with postoperative thrombosis is causal or coincidental is unclear due to inconsistent results from randomized clinical trials.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Fibrinolytic testing adds no value to symptomatic VTE risk assessment; confirms limited role outside postoperative settings.

Cite This Study

Martin H. Prins (1991) conducted a systematic review in Venous thromboembolism. Impaired fibrinolytic activity was evaluated on Venous thromboembolism. Impaired fibrinolytic activity lacks proven association with symptomatic thrombosis, but shows good evidence for an association with increased risk of postoperative thrombosis.

synapsesocial.com/papers/6aa8a500429840b7f5709b21 https://doi.org/10.1001/archinte.151.9.1721

View Full Paper

Ask AI

Bookmark

A critical review of the evidence supporting a relationship between impaired fibrinolytic activity and venous thromboembolism

Key Points

Study Design

Structured PICO

Limitations

Discussion

Implication

Cite This Study

A critical review of the evidence supporting a relationship between impaired fibrinolytic activity and venous thromboembolism

Key Points

Study Design

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider