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November 1, 1988Pacing and Clinical Electrophysiology

Hemodynamic Responses to Rapid Pacing: A Model for Tachycardia Differentiation

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Why the study?

Does rapid right ventricular pacing compared to right atrial pacing cause different hemodynamic responses in anesthetized dogs?

Population

10 closed-chest anesthetized dogs

Comparison

Rapid right ventricular apex pacing at rates of… vs High right atrial pacing at rates of 180, 250…

Design

Preclinical

Follow-up

60 seconds of pacing

Authors

TCTodd J. CohenUniversity of North Carolina at Chapel HillEVEnrico P. VeltriElectrophysiologyJLJ. John LattucaAbbott (Sweden)

Discussion

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Implication

May aid pressure-based VT detection in devices; hypothesis-generating for human translation.

Structured PICO

Does rapid right ventricular pacing compared to right atrial pacing cause different hemodynamic responses in anesthetized dogs?

P
Population
10 closed-chest anesthetized dogs
I
Intervention
Rapid right ventricular apex pacing at rates of 180, 250, and 280/minute
C
Comparator
High right atrial pacing at rates of 180, 250, and 280/minute, and baseline heart rates
O
Outcome
Hemodynamic responses including mean arterial pressure, mean right atrial pressure, and mean right ventricular pressure at 30 and 60 seconds of pacingsurrogate

Mean right atrial and right ventricular pressures can distinguish hemodynamically unstable ventricular tachycardias from stable atrial tachycardias in a canine model, informing antitachycardia device design.

Cite This Study

Cohen et al. (1988) studied this question.

synapsesocial.com/papers/6a71547235aa2c282ce2a2f4https://doi.org/10.1111/j.1540-8159.1988.tb06268.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of atrial and ventricular tachycardias on the cardiovascular dynamics1964 · 57 citations
  2. 2SYNCHRONICITY OF VENTRICULAR CONTRACTION: OBSERVATIONS COMPARING HAeMODYNAMIC EFFECTS OF ATRIAL AND VENTRICULAR PACING1963 · 201 citations
  3. 3Measurement of Differences in Timing and Sequence Between Two Ventricular Electrodes as a Means of Tachycardia Differentiation1986 · 25 citations
  4. 4Studies on Starling's Law of the Heart1961 · 466 citations
  5. 5A Theoretical Right Atrial Pressure Feedback Heart Rate Control System to Restore Physiologic Control to the Rate‐limited Heart1984 · 26 citations