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March 1, 1992Journal of Biological ChemistryOpen Access

Homologous desensitization of HEL cell thrombin receptors. Distinguishable roles for proteolysis and phosphorylation.

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Population

Megakaryoblastic HEL cell line

Design

Preclinical

Authors

LBLawrence F. BrassCross-Cutting Cardiology

Discussion

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Overview

Distinct thrombin receptor desensitization pathways may inform antiplatelet targeting; leaves open human translation and clinical relevance.

Structured PICO

P
Population
Megakaryoblastic HEL cell line
I
Intervention
Thrombin, TRP42/55 (a peptide corresponding to the N-terminal sequence of the receptor following proteolysis by thrombin), and 12-O-tetradecanoylphorbol-13-acetate (TPA)
O
Outcome
Mechanism of thrombin receptor desensitization and resensitizationsurrogate

Thrombin receptor desensitization occurs via two distinct mechanisms: proteolysis requiring new protein synthesis and phosphorylation.

Cite This Study

Lawrence F. Brass (1992) studied this question.

synapsesocial.com/papers/6a71551a6c240de38cdc19fahttps://doi.org/10.1016/s0021-9258(18)42659-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Thrombin-induced phosphoinositide hydrolysis in platelets. Receptor occupancy and desensitization1987 · 46 citations
  2. 2A new generation of Ca2+ indicators with greatly improved fluorescence properties.1985 · 21,790 citations
  3. 3Identification of the pertussis toxin-sensitive G proteins in platelets, megakaryocytes, and human erythroleukemia cells1990 · 95 citations
  4. 4Two distinct pathways for cAMP-mediated down-regulation of the β2-adrenergic receptor1989 · 272 citations
  5. 5Receptor and G protein-mediated responses to thrombin in HEL cells.1991 · 110 citations