Population
Xenopus oocytes expressing chimeric constructs and point mutants of GIRK1 (KIR3.1) and ROMK1 (KIR1.1)
Comparison
Heterologous expression of chimeric constructs… vs Wild-type channels or other constructs
Design
Preclinical
Authors
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Phe137 governs GIRK1 gating kinetics; extends channel biophysics but leaves open any therapeutic relevance in cardiovascular disease.
The P-region, specifically phenylalanine 137, is critical for the time-dependent gating of the G protein-activated inwardly rectifying potassium channel GIRK1.
Kofuji et al. (1996) studied this question.
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