Why the study?
Coxsackievirus B3 is an active pathogen causing myocarditis and other conditions, but its whole-genome diversity and recombination have not been systematically analyzed.
Population
CVB3 isolates from national HFMD surveillance and global sequences from GenBank
Design
Phylogenetic and whole-genome analysis
Authors
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CVB3 genomic surveillance warranted amid recombination; leaves open virulence associations in myocarditis and HFMD.
Whole-genome analysis of CVB3 reveals 5 global clusters, with cluster D predominating in China, and identifies 23 recombinant lineages circulating worldwide.
Yang et al. (2022) studied this question.
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