The 950Tyr residue of the human IGF-I receptor is required for IGF-I signal transduction in pituitary somatotrophs, but not for ligand internalization.
No takes yet. Share an insight, caveat, or question.
Leaves open IGF-IR 950Tyr as a GH-regulatory target; requires in vivo validation before clinical consideration.
Yamasaki et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: