November 1, 1992Endocrinology

Rat somatotroph insulin-like growth factor-II (IGF-II) signaling: role of the IGF-I receptor.

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Population

Primary rat somatotrophs and GC rat pituitary cells

Comparison

Recombinant human IGF-II, [Leu27]IGF-II, and… vs IGF-I and varying concentrations of IGF-II

Design

Preclinical

Authors

MWMatthias M. WeberJohannes Gutenberg University Mainz ШМШломо МелмедNorthwestern University JRJ. RosenbloomThomas Jefferson University

Discussion

Member takes

Implication

Rat somatotroph findings suggest IGF-II inhibits GH via IGF-I receptors; leaves open human relevance and requires in vivo validation.

Structured PICO

Population

Primary rat somatotrophs and GC rat pituitary cells (including transfected GH-secreting cell lines overexpressing intact or truncated human IGF-I receptors)

Intervention

Recombinant human IGF-II, [Leu27]IGF-II, and [Arg54,Arg55]IGF-II

Comparator

IGF-I and varying concentrations of IGF-II

Outcome

Growth hormone (GH) secretion and [125I]IGF-I binding affinitysurrogate

IGF-II regulates polypeptide hormone secretion in rat somatotrophs via the IGF-I receptor.

Cite This Study

Weber et al. (1992) studied this question.

synapsesocial.com/papers/6a8968c41acf8e321fbd567c https://doi.org/10.1210/endo.131.5.1425415

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Bookmark

Rat somatotroph insulin-like growth factor-II (IGF-II) signaling: role of the IGF-I receptor.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Rat somatotroph insulin-like growth factor-II (IGF-II) signaling: role of the IGF-I receptor.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider