July 1, 1996EndocrinologyOpen Access

Insulin-like growth factor I and insulin down-regulate growth hormone (GH) receptors in rat osteoblasts: evidence for a peripheral feedback loop regulating GH action.

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Population

UMR106.06, a well differentiated rat osteoblast-like cell line

Comparison

IGF-I and insulin (0-10 nM) vs Control (untreated cells)

Design

Preclinical

Authors

KLK C LeungGarvan Institute of Medical Research IRI A RajkovicGarvan Institute of Medical Research EPElisabeth PetersLaboklin (Germany)

Discussion

Member takes

Implication

Does not warrant clinical changes; hypothesis-generating for peripheral GH receptor feedback in bone.

Structured PICO

Population

UMR106.06, a well differentiated rat osteoblast-like cell line

Intervention

IGF-I and insulin (0-10 nM)

Comparator

Control (untreated cells)

Outcome

Cell number and [125I]GH bindingsurrogate

IGF-I and insulin stimulate cell proliferation and down-regulate GH receptors in osteoblasts, suggesting a peripheral negative feedback loop regulating GH action.

Cite This Study

Leung et al. (1996) studied this question.

synapsesocial.com/papers/6a8a4e8f0e1a8f7244fd6ff0 https://doi.org/10.1210/endo.137.7.8770888

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Bookmark

Insulin-like growth factor I and insulin down-regulate growth hormone (GH) receptors in rat osteoblasts: evidence for a peripheral feedback loop regulating GH action.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Insulin-like growth factor I and insulin down-regulate growth hormone (GH) receptors in rat osteoblasts: evidence for a peripheral feedback loop regulating GH action.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider