Why the study?
Fetal aortic valvuloplasty may prevent progression of severe fetal aortic stenosis to hypoplastic left heart syndrome, but it is high risk, requiring careful selection between prenatal treatment and waiting for postnatal intervention.
Does prenatal fetal aortic balloon valvuloplasty prevent progression to hypoplastic left heart syndrome compared to postnatal intervention in fetuses with severe aortic stenosis?
Does prenatal fetal aortic balloon valvuloplasty prevent progression to hypoplastic left heart syndrome compared to postnatal intervention in fetuses with severe aortic stenosis?
Careful selection of fetuses with severe aortic stenosis is required to balance the high risks of prenatal balloon valvuloplasty against the benefit of preventing hypoplastic left heart syndrome.
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High-risk fetal aortic valvuloplasty demands strict selection; leaves open optimal criteria versus postnatal intervention.
Fetal aortic valvuloplasty may prevent the progression of severe fetal aortic stenosis to hypoplastic left heart syndrome at birth. Since it is an high risk procedure a careful selection of fetuses that can benefit from the prenatal treatment instead of waiting for postnatal intervention.
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Rizzo et al. (2022) studied this question.
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