What question did this study set out to answer?

To determine the temporal progression and regional distribution of myocardial cationic electrolyte alterations following acute coronary artery ligation.

May 1, 1975CirculationOpen Access

Time course and zonal variations of ischemia-induced myocardial cationic electrolyte derangements.

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Authors

JLJ T LieGuangdong Medical College PPPeter C. PairoleroCegep de Sainte Foy KHKeith E. HolleyUniversity of Minnesota

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Implication

Supports further investigation of cation shifts in ischemia; leaves open translation to human myocardial infarction management.

Key Points

To determine the temporal progression and regional distribution of myocardial cationic electrolyte alterations following acute coronary artery ligation.
Conducted coronary artery ligation in dogs, measuring myocardial cationic electrolytes at regular intervals up to 24 hours.
Computed and compared replicate electrolyte ratios across the infarct proper (ZONE I), border areas (ZONE B), remote areas (ZONE N), and sham controls.
Tissue K+/Na+ and Mg++/Ca++ ratios in ZONE I fell precipitously within the first hour post-ligation and gradually approached extracellular fluid levels by 24 hours.
Histologically normal border tissue (ZONE B) showed parallel downward electrolyte shifts that differed significantly in magnitude from ZONE I (P < 0.01).
Remote myocardial tissue (ZONE N) displayed small electrolyte derangements that did not consistently overlap with sham-operated baseline values.

Cite This Study

Lie et al. (1975) studied this question.

synapsesocial.com/papers/6a715dbefebe604dd70a096d https://doi.org/10.1161/01.cir.51.5.860

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Time course and zonal variations of ischemia-induced myocardial cationic electrolyte derangements.

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Implication

Key Points

Cite This Study

Time course and zonal variations of ischemia-induced myocardial cationic electrolyte derangements.

Discussion

Member takes

Implication

Key Points

Cite This Study

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