December 1, 1975Circulation ResearchOpen Access

Expansion of extracellular space in the nonischemic zone of the infarcted heart and concomitant changes in tissue electrolyte contents in the rat.

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Population

Rat model of myocardial infarction

Design

Preclinical

Authors

PPPhilip I. PolimeniState University of New York JAJafar Al‐SadirUniversity of Chicago

Discussion

Member takes

Implication

Hypothesis-generating in rat MI models; human studies needed before any clinical relevance.

Structured PICO

Population

Rat model of myocardial infarction

Intervention

Myocardial infarction

Outcome

Electrolyte content (sodium, calcium, chloride, potassium, magnesium) and extracellular space in the nonischemic zonesurrogate

Expansion of the extracellular space in the nonischemic zone of infarcted rat hearts accounts for most electrolyte changes, except for calcium, which may increase as a compensatory mechanism to enhance contractility.

Cite This Study

Polimeni et al. (1975) studied this question.

synapsesocial.com/papers/6a90f7d6b24842dac47a6df4 https://doi.org/10.1161/01.res.37.6.725

View Full Paper

Ask AI

Bookmark

Expansion of extracellular space in the nonischemic zone of the infarcted heart and concomitant changes in tissue electrolyte contents in the rat.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Expansion of extracellular space in the nonischemic zone of the infarcted heart and concomitant changes in tissue electrolyte contents in the rat.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider