What question did this study set out to answer?

Describe the varied clinical manifestations, including severe encephalitis, and evaluate diagnostic laboratory methods in a family cluster infected with monkeypox virus.

October 26, 2004The Journal of Infectious DiseasesOpen Access

Human Monkeypox Infection: A Family Cluster in the Midwestern United States

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Authors

JSJames J. SejvarCenters for Disease Control and Prevention YCYalamanchali Chowdary MSMark SchomogyiUniversity of Washington

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Implication

Case series reveals variable clinical severity including encephalitis in a family exposed to monkeypox virus, highlighting the potential protective effect of prior smallpox vaccination.

Key Points

Describe the varied clinical manifestations, including severe encephalitis, and evaluate diagnostic laboratory methods in a family cluster infected with monkeypox virus.
Reviewed medical charts and administered standardized questionnaires for 3 family members with laboratory-confirmed monkeypox during the June 2003 Midwestern United States outbreak.
Tested clinical specimens via viral culture, polymerase chain reaction (PCR), serologic assays, histopathology, and immunohistochemical analysis.
Across 3 family members with a common exposure, 2 exhibited febrile rash illness alone, while 1 developed severe encephalitis requiring intensive hospitalization.
The individual with the mildest illness course had a history of prior smallpox vaccination.
Polymerase chain reaction and viral culture confirmed viable monkeypox virus in skin lesions of all 3 patients, with orthopoxvirus-reactive IgM detected in the cerebrospinal fluid of the encephalitis case.

Cite This Study

Sejvar et al. (2004) studied this question.

synapsesocial.com/papers/6a715fac3ce530166bc313fa https://doi.org/10.1086/425039

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Implication

Case series reveals variable clinical severity including encephalitis in a family exposed to monkeypox virus, highlighting the potential protective effect of prior smallpox vaccination.

Human Monkeypox Infection: A Family Cluster in the Midwestern United States

Discussion

Member takes

Implication

Key Points

Cite This Study

Human Monkeypox Infection: A Family Cluster in the Midwestern United States

Discussion

Member takes

Implication

Key Points

Cite This Study

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