Why the study?
Does treatment with exogenous interferon, poly(I:C), or P-L-L complex reduce mortality in mice with encephalomyocarditis virus infections?
Population
Mice with encephalomyocarditis virus infections (inoculated by either intraperitoneal or intranasal route)
Design
Preclinical
Authors
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P-L-L complex merits further preclinical testing; leaves open whether interferon induction translates to human antiviral efficacy.
Does treatment with exogenous interferon, poly(I:C), or P-L-L complex reduce mortality in mice with encephalomyocarditis virus infections?
P-L-L complex is highly effective in protecting mice against encephalomyocarditis virus infection by inducing high levels of interferon and preventing viremia.
Olsen et al. (1976) studied this question.
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