What question did this study set out to answer?

To assess how single doses of polyriboinosinic-polyribocytidylic acid and tilorone hydrochloride influence viral pathogenesis and disease outcome in mice infected with encephalomyocarditis virus.

November 1, 1974The Journal of Infectious Diseases

Interferon Inducers in Therapy of Infection with Encephalomyocarditis Virus in Mice. I. Effect of Single Doses of Polyriboinosinic-Polyribocytidylic Acid and Tilorone Hydrochloride on Viral Pathogenesis

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Why the study?

Does a single dose of poly I: poly C or tilorone hydrochloride prevent lethal consequences in mice infected with encephalomyocarditis virus?

Key Points

To assess how single doses of polyriboinosinic-polyribocytidylic acid and tilorone hydrochloride influence viral pathogenesis and disease outcome in mice infected with encephalomyocarditis virus.
Inoculated mice with encephalomyocarditis virus to establish an animal model simulating enteroviral infection.
Administered single doses of either polyriboinosinic-polyribocytidylic acid (poly I:poly C) or tilorone hydrochloride prophylactically and at various stages post-infection.
Analyzed individual animals longitudinally to track viremia, viral dissemination to the central nervous system, and mortality.
Both poly I:poly C and tilorone protected animals from death when given prophylactically, but therapeutic efficacy declined progressively as infection advanced.
Successful therapy in every case was marked by complete suppression of detectable viremia, whereas detection of circulating virus was invariably followed by mortality.
Viremia directly facilitated viral seeding and replication within the central nervous system.

Structured PICO

Does a single dose of poly I: poly C or tilorone hydrochloride prevent lethal consequences in mice infected with encephalomyocarditis virus?

Population

Mice inoculated with encephalomyocarditis virus

Intervention

Single dose of either polyriboinosinic-polyribocytidylic acid (poly I: poly C) or tilorone hydrochloride

Outcome

Lethal consequences of the disease (survival) and suppression of viremiahard clinical

Prophylactic administration of interferon inducers poly I: poly C or tilorone hydrochloride protects mice from lethal encephalomyocarditis virus infection by completely suppressing viremia.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating for prophylactic interferon induction in viral infections; requires human studies before any clinical consideration.

Cite This Study

Stringfellow et al. (1974) studied this question.

synapsesocial.com/papers/6a716120ac440176ef2a0e34 https://doi.org/10.1093/infdis/130.5.470

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Implication

Hypothesis-generating for prophylactic interferon induction in viral infections; requires human studies before any clinical consideration.

Interferon Inducers in Therapy of Infection with Encephalomyocarditis Virus in Mice. I. Effect of Single Doses of Polyriboinosinic-Polyribocytidylic Acid and Tilorone Hydrochloride on Viral Pathogenesis

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Interferon Inducers in Therapy of Infection with Encephalomyocarditis Virus in Mice. I. Effect of Single Doses of Polyriboinosinic-Polyribocytidylic Acid and Tilorone Hydrochloride on Viral Pathogenesis

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider