Why the study?
Does intra-arterial fasudil improve increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure?
Population
52 subjects, comprising 26 patients with heart failure (HF group) and 26 age-matched controls.
Comparison
Intra-arterial infusion of graded doses of… vs Intra-arterial infusion of sodium nitroprusside…
Design
Cross-sectional
Authors
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Supports Rho-kinase contribution to HF vascular resistance; leaves open therapeutic potential of inhibition.
Does intra-arterial fasudil improve increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure?
Intra-arterial infusion of the Rho-kinase inhibitor fasudil improves increased forearm vascular resistance and impaired vasodilation in patients with heart failure, suggesting Rho-kinase involvement in peripheral circulation abnormalities.
Kishi et al. (2005) studied this question.
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