May 1, 1998Clinical ChemistryOpen Access

Immunoradiometric assay for the N-terminal fragment of proatrial natriuretic peptidein human plasma

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Structured PICO

Population

33 healthy subjects and 25 patients with heart failure (total n=58)

Intervention

Two-step immunoradiometric assay using monoclonal antibodies and synthetic N-terminal proANP (1-67) as a standard

Outcome

Assay performance characteristics (detection limit, precision, linearity, recovery) and plasma N-terminal proANP levelssurrogate

The developed two-step immunoradiometric assay provides a rapid and precise method for measuring N-terminal proANP, a marker of heart failure, in human plasma without prior extraction.

Discussion

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Implication

Facilitates precise NT-proANP measurement in plasma; leaves open its diagnostic role in heart failure pending clinical validation.

Cite This Study

Numata et al. (1998) studied this question.

synapsesocial.com/papers/6a71628235aa2c282ce2aec7 https://doi.org/10.1093/clinchem/44.5.1008

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Immunoradiometric assay for the N-terminal fragment of proatrial natriuretic peptidein human plasma

Structured PICO

Discussion

Implication

Cite This Study

Immunoradiometric assay for the N-terminal fragment of proatrial natriuretic peptidein human plasma

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider