Plasma levels and molecular forms of proatrial natriuretic peptides in healthy subjects and in patients with congestive heart failure

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Why the study?

Are plasma levels of NproANP a more sensitive marker of left ventricular dysfunction than ANP in patients with congestive heart failure?

Structured PICO

Are plasma levels of NproANP a more sensitive marker of left ventricular dysfunction than ANP in patients with congestive heart failure?

Population

Healthy subjects and patients with congestive heart failure (26 with dilated cardiomyopathy and 5 with ischemic heart disease, NYHA classes I-III).

Intervention

Measurement of plasma concentrations of proANP(1-30) and ANP immunoreactivities using a specific radioimmunoassay.

Comparator

Healthy subjects

Outcome

Plasma levels of ir-proANP(1-30) and ir-ANPsurrogate

NproANP plasma levels may be a more sensitive marker of early left ventricular dysfunction than ANP in patients with congestive heart failure.

Authors

No takes yet. Share an insight, caveat, or question.

NproANP may detect early LV dysfunction more sensitively than ANP; leaves open clinical adoption pending prospective validation.

Azizi et al. (1996) studied this question.

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