Why the study?
Are plasma levels of N-terminal atrial natriuretic peptide and atrial natriuretic peptide elevated in patients with essential hypertension, cardiac transplant, and chronic renal failure compared to normal subjects?
Population
95 subjects, including normal subjects, patients with essential hypertension, cardiac transplant recipients…
Comparison
Measurement of plasma levels of N-terminal… vs Normal subjects
Design
Cross-sectional
Authors
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Elevated N-terminal pro-ANP across these conditions supports biomarker exploration; hypothesis-generating and should not yet change practice.
Are plasma levels of N-terminal atrial natriuretic peptide and atrial natriuretic peptide elevated in patients with essential hypertension, cardiac transplant, and chronic renal failure compared to normal subjects?
Immunoreactive N-terminal atrial natriuretic peptide and atrial natriuretic peptide are significantly elevated in patients with essential hypertension, cardiac transplant, and chronic renal failure, primarily circulating as a high-molecular-mass form.
Buckley et al. (1994) studied this question.
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