April 1, 2002Journal of Applied Physiology

Estrogen attenuates the cardiovascular and ventilatory responses to central command in cats

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Population

Decerebrate male cats

Design

Preclinical

Authors

SHShawn G. HayesCapitol Technology University NPNicolas B. Moya Del Pino MKMarc P. KaufmanGeneral Cardiology

Discussion

Member takes

Implication

Indicates potential mechanism for sex differences in exercise responses; hypothesis-generating and not yet applicable to clinical practice.

Structured PICO

Population

Decerebrate male cats

Intervention

17beta-estradiol (0.001, 0.01, 0.1, and 1.0 microg/kg iv)

Outcome

Cardiovascular (pressor, cardioaccelerator) and ventilatory (phrenic nerve) responses to electrical stimulation of the mesencephalic locomotor region (central command) and static contraction or stretch of the triceps surae muscles (exercise pressor reflex)surrogate

In a feline model, intravenous estrogen attenuates cardiovascular and ventilatory responses to central command but not to the exercise pressor reflex, suggesting a specific neural mechanism for sex differences in exercise response.

Cite This Study

Hayes et al. (2002) studied this question.

synapsesocial.com/papers/6a7162b1febe604dd70a0da6 https://doi.org/10.1152/japplphysiol.00981.2001

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Implication

Indicates potential mechanism for sex differences in exercise responses; hypothesis-generating and not yet applicable to clinical practice.

Estrogen attenuates the cardiovascular and ventilatory responses to central command in cats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Estrogen attenuates the cardiovascular and ventilatory responses to central command in cats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider