Population
Scallop myosin S1 (intact scallop myosin head containing both the motor domain and the lever arm)
Comparison
Nucleotide-free state and presence of MgADP.V04 vs MgADP complexed state (detached ATP state)
Design
Preclinical
Authors
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No direct clinical application yet; leaves open isoform-specific myosin compliance for targeted cardiac research.
The study reveals three conformations of scallop myosin S1, showing that the heavy-chain helix is pliant at the junction between the converter and lever arm, which may contribute to crossbridge compliance.
Houdusse et al. (2000) studied this question.
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