Population
Nucleotide-free (apo) striated muscle myosin-2 subfragment-1 (S1) from rabbit, scallop, and chicken
Design
Preclinical
Authors
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Does not support changes to cardiac myosin therapies; extends models of lever flexibility and actin-induced stiffening.
The flexibility of the myosin-2 motor-lever junction is thermally driven, and its relatively low stiffness suggests that binding to actin leads to allosteric stiffening.
Billington et al. (2013) studied this question.
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