Why the study?
Does correction of metabolic or respiratory acidosis with THAM improve ventricular isometric systolic tension and the response to levarterenol?
Population
Preclinical model (animal model implied)
Comparison
Induction of metabolic or respiratory acidosis… vs Baseline state before acidosis or uncorrected…
Design
Preclinical
Authors
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Hypothesis-generating for THAM in acidotic cardiac dysfunction; clinical trials needed before any practice change.
Does correction of metabolic or respiratory acidosis with THAM improve ventricular isometric systolic tension and the response to levarterenol?
Correction of acidosis with THAM improves ventricular systolic tension and responsiveness to catecholamines in preclinical models of shock.
Darby et al. (1960) studied this question.
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