Why the study?
Does progression of carotid atherosclerosis affect cognitive function in middle-aged stroke-free individuals?
Population
4,274 middle-aged stroke-free subjects from the population-based Tromsø study
Design
Cohort
Follow-up
7 years (initial) and additional 6 years for subgroup
Authors
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May mark early domain-specific cognitive vulnerability; hypothesis-generating and should not change practice without prospective confirmation.
Does progression of carotid atherosclerosis affect cognitive function in middle-aged stroke-free individuals?
Progression of carotid artery plaque is associated with lower scores in specific cognitive tests but not with overall cognitive decline in middle-aged stroke-free individuals.
Arntzen et al. (2012) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: