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June 30, 2016British Medical BulletinOpen Access

Heart failure—potential new targets for therapy

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Population

Patients with heart failure

Design

Review

Authors

ANAdam NabeebaccusSZSean L. ZhengASAjay M. Shah

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Overview

Supports current HF guidelines and trial therapies; leaves open validation of basic science targets in practice.

Structured PICO

P
Population
Patients with heart failure (including chronic heart failure with reduced left ventricular function and heart failure with preserved left ventricular function)
I
Intervention
Emerging therapies and potential new therapeutic targets (e.g., targeting natriuretic peptides, myosin activators, extracellular environment, angiogenesis, cell viability, contractile function, and microRNA-based therapies)

This review outlines current and emerging therapeutic targets for heart failure, emphasizing the need for targeted therapies based on underlying pathophysiological mechanisms.

Cite This Study

Nabeebaccus et al. (2016) studied this question.

synapsesocial.com/papers/6a716eab6c240de38cdc235ahttps://doi.org/10.1093/bmb/ldw025
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