Why the study?
Does age affect the pharmacokinetics and pharmacodynamics of enalapril and enalaprilat in healthy volunteers?
Does age affect the pharmacokinetics and pharmacodynamics of enalapril and enalaprilat in healthy volunteers?
Age-related declines in renal function and changes in body composition alter the pharmacokinetics of enalapril and enalaprilat, which partly explains the greater pharmacodynamic response observed in elderly patients.
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May warrant cautious enalapril dosing in elderly; hypothesis-generating for PK effects in patients with comorbidities.
Hockings et al. (1986) studied this question.
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