Why the study?
With population aging, selecting an effective regimen for arterial hypertension is increasingly important, motivating comparison of pharmacokinetic and pharmacodynamic properties of parent and generic enalapril in elderly patients.
Does original enalapril improve pharmacokinetic profiles and blood pressure reduction compared to generic enalapril in elderly patients with arterial hypertension?
Does original enalapril improve pharmacokinetic profiles and blood pressure reduction compared to generic enalapril in elderly patients with arterial hypertension?
Original enalapril provides significantly higher plasma concentrations and more sustained blood pressure reduction compared to generic enalapril in elderly patients with arterial hypertension.
Authors
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May support generic enalapril use in elderly AH; leaves open need for confirmatory trials.
Mikhailova et al. (2022) studied this question.
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