Key result
Enalapril reduced systolic and diastolic blood pressure by 13% and 14% respectively, with no difference in percentage change across age groups, contrary to predictions of reduced efficacy in the elderly.
Why the study?
Does enalapril reduce blood pressure effectively across all age groups in patients with essential hypertension?
Observational (n=11,710)
Does enalapril reduce blood pressure effectively across all age groups in patients with essential hypertension?
Enalapril is equally effective in reducing blood pressure across all age groups when corrected for baseline blood pressure, challenging the hypothesis that ACE inhibitors are less effective in the elderly.
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Supports similar enalapril BP reduction across ages in hypertension; challenges age-related efficacy assumptions but leaves open confirmation in randomized trials.
Cooper et al. (2009) conducted an observational in essential hypertension (n=11,710). Enalapril vs. Pre-treatment baseline was evaluated on Blood pressure response and symptom events. Enalapril reduced systolic and diastolic blood pressure by 13% and 14% respectively, with no difference in percentage change across age groups, contrary to predictions of reduced efficacy in the elderly.
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