Why the study?
Does adrenergic blockade alter the pressor response to angiotensin in the perfused hind limb of anesthetized dogs?
Does adrenergic blockade alter the pressor response to angiotensin in the perfused hind limb of anesthetized dogs?
Adrenergic blockade does not significantly alter the pressor response to angiotensin in the perfused hind limb of anesthetized dogs, suggesting angiotensin does not cause catecholamine release in this model.
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Adrenergic blockade leaves angiotensin pressor effects intact in this canine model; leaves open relevance to other species or vascular beds.
The ability of angiotensin to cause release of catecholamines from adrenergic nerve endings was studied in anesthetized dogs in which the femoral vascular bed was perfused at constant flow and in which reflexly induced changes in perfusion pressure were abolished by epidural blockade. Magnitude and rate of development of the pressor response to angiotensin were examined prior to blockade and after alpha adrenergic blockade with phenoxybenzamine or beta adrenergic blockade with propranolol. No significant alterations in the pressor response were observed following adrenergic receptor blockade. As no evidence was obtained for release of catecholamines by angiotensin in this preparation, any effects of angiotensin on reuptake of catecholamines would not be tested.
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Robert F. Lowe (1970) studied this question.
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