Key result
Pretreatment with an alpha 1-adrenergic antagonist or ACE inhibitor attenuated hypertension during aortic cross-clamping in rats, whereas beta- or alpha 2-adrenergic antagonists exacerbated it.
Why the study?
Does pretreatment with adrenoceptor or renin-angiotensin system antagonists alter the hemodynamic response to thoracic aortic cross-clamping in anesthetized rats?
Does pretreatment with adrenoceptor or renin-angiotensin system antagonists alter the hemodynamic response to thoracic aortic cross-clamping in anesthetized rats?
The renin-angiotensin and sympathetic nervous systems play important roles in the hemodynamic response to thoracic aortic cross-clamping, with alpha-1 and ACE inhibition attenuating the hypertensive response.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating for alpha-1 or ACE inhibition in aortic cross-clamping; human studies needed before clinical translation.
Sun-Ae Hahm Hong (1992) studied Hemodynamic response to aortic cross-clamping. Adrenoceptor and renin-angiotensin system antagonists vs. Saline was evaluated on Hemodynamic response (mean arterial pressure, systemic vascular resistance, cardiac output). Pretreatment with an alpha 1-adrenergic antagonist or ACE inhibitor attenuated hypertension during aortic cross-clamping in rats, whereas beta- or alpha 2-adrenergic antagonists exacerbated it.
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