Key result
Pretreatment with Enalaprilat prevented the 33-45% increase in limb vascular resistance seen in controls during aortic cross-clamping, while phenoxybenzamine decreased it to 43% of preclamped levels.
Why the study?
Does pretreatment with Enalaprilat or phenoxybenzamine alter limb vascular resistance during thoracic aorta cross-clamping in dogs?
Does pretreatment with Enalaprilat or phenoxybenzamine alter limb vascular resistance during thoracic aorta cross-clamping in dogs?
Angiotensin and catecholamines mediate systemic hemodynamic changes, such as arterial hypertension, during thoracic aorta cross-clamping.
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No immediate clinical implications for aortic procedures; leaves open translation of vascular resistance effects to human trials.
Gelman et al. (1990) studied Hemodynamic response to cross-clamping of the thoracic aorta (n=21). Enalaprilat or phenoxybenzamine vs. Denervated control animals was evaluated on Limb vascular resistance. Pretreatment with Enalaprilat prevented the 33-45% increase in limb vascular resistance seen in controls during aortic cross-clamping, while phenoxybenzamine decreased it to 43% of preclamped levels.
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