Key result
Nicardipine prevented the decreases in glomerular filtration rate (42.9%) and effective renal plasma flow (18.5%) seen in placebo patients during aortic cross-clamping.
Why the study?
Does nicardipine or enalapril prevent renal hemodynamic impairment during infrarenal aortic cross-clamping in patients undergoing reconstructive aortic surgery?
Population
24 patients scheduled for reconstructive aortic surgery
Comparison
Nicardipine or enalapril vs Placebo
Design
RCT, Randomly allocated to one of three treatment groups
Follow-up
Duration of aortic cross-clamping
Authors
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Supports nicardipine to preserve renal hemodynamics during aortic cross-clamping; confirms calcium channel blockade benefit over ACE inhibition.
RCT (n=24)
Randomly allocated
Does nicardipine or enalapril prevent renal hemodynamic impairment during infrarenal aortic cross-clamping in patients undergoing reconstructive aortic surgery?
p-value: p=<0.05
Nicardipine, but not enalapril, prevents the decrease in glomerular filtration rate and effective renal plasma flow associated with infrarenal aortic cross-clamping, suggesting calcium channel blockade alleviates renal vasoconstriction.
Colson et al. (1992) conducted an RCT in Scheduled for reconstructive aortic surgery (n=24). Nicardipine or enalapril vs. Placebo was evaluated on Glomerular filtration rate and effective renal plasma flow (p=<0.05). Nicardipine prevented the decreases in glomerular filtration rate (42.9%) and effective renal plasma flow (18.5%) seen in placebo patients during aortic cross-clamping.
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