Why the study?
Does felodipine, enalapril, or their combination improve renal microcirculation and reduce blood pressure in spontaneously hypertensive rats with or without L-NAME?
Population
19-week-old spontaneously hypertensive rats with or without N-nitro-L-arginine methyl ester cotreatment
Comparison
Felodipine, enalapril, or felodipine plus… vs Control or L-NAME only
Design
Preclinical
Follow-up
3 to 6 weeks
Authors
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Provides preclinical support for these agents in nephrosclerosis; leaves open whether effects extend to patients.
Does felodipine, enalapril, or their combination improve renal microcirculation and reduce blood pressure in spontaneously hypertensive rats with or without L-NAME?
Felodipine, alone or combined with enalapril, prevents and reverses L-NAME-exacerbated hypertensive nephrosclerosis in spontaneously hypertensive rats.
Francischetti et al. (1998) studied this question.
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