What question did this study set out to answer?

To evaluate the capacity and physiological growth characteristics of three Claviceps purpurea isolates to synthesize peptide ergot alkaloids in submerged culture.

September 1, 1969Applied MicrobiologyOpen Access

Production of Peptide Ergot Alkaloids in Submerged Culture by Three Isolates of Claviceps purpurea

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Authors

AAA. AmiciUniversità degli Studi della Tuscia AMA. MinghettiIstituto di Biologia e Biotecnologia Agraria TST. ScottiRutgers, The State University of New Jersey

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Implication

Laboratory study reveals distinct peptide ergot alkaloid production in three Claviceps purpurea isolates, indicating nutrient depletion drives secondary metabolite synthesis.

Key Points

To evaluate the capacity and physiological growth characteristics of three Claviceps purpurea isolates to synthesize peptide ergot alkaloids in submerged culture.
Cultivated three Claviceps purpurea strains isolated from rye sclerotia in submerged fermentation culture.
Monitored conidia production, nutrient uptake (phosphate, ammonium nitrogen, and citric acid), biomass growth, and metabolite accumulation throughout fermentation.
The three isolates produced distinct peptide alkaloid profiles in submerged conditions: ergocryptine with ergotamine, ergocornine with ergosine, and ergocristine alone, respectively.
Fermentation progressed in two distinct phases: an initial rapid growth phase featuring rapid exhaustion of phosphate, ammonium, and citric acid with low alkaloid production, followed by a secondary phase marked by slower growth and high accumulation of alkaloids, sterols, and lipids.

Cite This Study

Amici et al. (1969) studied this question.

synapsesocial.com/papers/6a717a12ce524a4339c4ff1b https://doi.org/10.1128/am.18.3.464-468.1969

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Implication

Laboratory study reveals distinct peptide ergot alkaloid production in three Claviceps purpurea isolates, indicating nutrient depletion drives secondary metabolite synthesis.

Production of Peptide Ergot Alkaloids in Submerged Culture by Three Isolates of Claviceps purpurea

Discussion

Member takes

Implication

Key Points

Cite This Study

Production of Peptide Ergot Alkaloids in Submerged Culture by Three Isolates of Claviceps purpurea

Discussion

Member takes

Implication

Key Points

Cite This Study

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